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Clinical trials of the new 3-dimensional reticular intrauterine device for reproductive women

Qiu Yi,Wang Leiguang and Yu Ling

Strategic Study of CAE 2014, Volume 16, Issue 5,   Pages 39-46

Abstract: reticular intrauterine device (3-DR-IUD) composed of nitinol and silicone rubber and observing the contraceptiveefficacy and side effects of the device in reproductive women.Therefore，the 3-DR-IUD demonstrates long-term patient tolerability，satisfaction and efficacy as a contraceptive.The

Keywords： 3-DR-IUD     clinical trials     side effects     contraceptive efficacy    

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Evaluation of effect of post-abortion contraceptive counseling and education on contraceptive behavior

Yuan Qinqin,Xu Liangzhi,Su Mi and Nie Ying

Strategic Study of CAE 2014, Volume 16, Issue 5,   Pages 34-38

Abstract:

To evaluate the effect of post- abortion contraceptive counseling andeducation (PACE) on contraceptive behavior of abortion women，200 women who had abortion in the WestIt was better for intervention group than conventional group on using contraceptive methods correctlyThe rates of modern contraceptive（such as condom，oral contraceptive pills and intrauterine devices）usagetheir contraceptive awareness，increase contraceptive knowledge and use correct contraceptive methods

Keywords： abortion     post- abortion contraceptive counseling and education     contraceptive behavior    

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Meta-analysis of the risk factors of breast cancer concerning reproductive factors and oral contraceptive

Qiong DAI MD, Bei LIU MD, Yukai DU MM,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 452-458 doi: 10.1007/s11684-009-0080-z

Abstract: performed a meta-analysis of case-control studies that addressed whether reproductive factors and oral contraceptiveage >50yr [odds ratio (OR), 1.39; 95% confidence interval (CI), 1.22―1.57] and oral contraceptiveMenopausal age >50yr and oral contraceptive use are positively correlated with an increase

Keywords： meta-analysis     breast cancer     risk factors     reproductive factors     oral contraceptive use    

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A review of the safety and efficacy of current COVID-19 vaccines

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 39-55 doi: 10.1007/s11684-021-0893-y

Abstract: This study reviewed the efficacy/effectiveness, immunogenicity, and safety profile of the 12 most progressedOverall, most of the current vaccines have shown safety and efficacy/effectiveness during actual clinical

Keywords： COVID-19     SARS-CoV-2     vaccine     safety     efficacy     effectiveness     immunogenicity    

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The status of contraceptive methods uses among women at reproductive age of migrants from different races

Zhang Junxian,Yang Ting,Xu Xiaofan,Long Chunyan,Liu Jiansu,Li Li

Strategic Study of CAE 2015, Volume 17, Issue 6,   Pages 57-60

Abstract: qualified subjects aged from 18 to 50 years old, and questionnaire survey including basic information and contraceptiveThe proportion of contraception use was 92.78 %, and among those who use contraceptive method, IUD was65.74 %, contraceptive drug was 23.17 %, condom was 9.06 % and sterilization was 2.03 %.education, occupation, marriage status and frequency of sexual life were the influencing factors of contraceptiveConclusions：Personalized and targeted services about informed choice of contraceptive use should be conducted

Keywords： floating women at reproductive age     contraceptive methods     using status    

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Heterogeneous influence of individuals’ behavior on mask efficacy in gathering environments

Frontiers of Engineering Management   Pages 550-562 doi: 10.1007/s42524-022-0193-5

Abstract: Although masks can slow down the spread of viruses, their efficacy in gathering environments involvingThe heterogeneity of individuals can cause mask efficacy in a specific gathering environment to be differentfrom the baseline efficacy in general society.This study contributes to the accurate evaluation of mask efficacy in various gathering environments

Keywords： COVID-19     masks     behavioral heterogeneity     asymptomatic infection    

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Retrospective study of the efficacy and complication of thoracoabdominal incision for nephrectomy: a

Minggen YANG, Xiaokun ZHAO

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 191-196 doi: 10.1007/s11684-009-0026-5

Abstract: Efficacy and complication was comparable for thoracoabdominal and flank incisions in terms of incisional

Keywords： surgery     renal tumors     nephrectomy    

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Family planning technical services in China

Shang-Chun WU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 285-289 doi: 10.1007/s11684-010-0097-3

Abstract: In order to ensure that people use safe, effective, and appropriate contraceptive methods based on theThe people can access various and convenient contraceptive services.In urban areas, all contraceptive services are free.The contraceptive prevalence rate in 2007 was 84.6%, the percentage of intrauterine device (IUD) wasAt the same time, the government gives priority to supporting research on contraceptive technology.

Keywords： family planning     contraceptive method     service delivery    

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Observation on therapeutic efficacy of ursodeoxycholic acid in Chinese patients with primary biliary

Jiangyi Zhu, Yongquan Shi, Xinmin Zhou, Zengshan Li, Xiaofeng Huang, Zheyi Han, Jianhong Wang, Ruian Wang, Jie Ding, Kaichun Wu, Ying Han, Daiming Fan

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 255-263 doi: 10.1007/s11684-012-0227-1

Abstract:

The efficacy of ursodeoxycholic acid (UDCA) on long-term outcome of primary biliary cirrhosis (PBC

Keywords： primary biliary cirrhosis     ursodeoxycholic acid     Chinese     biochemical response     therapeutic efficacy    

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Potential unreliability of ALK variant allele frequency in the efficacy prediction of targeted therapy

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 493-502 doi: 10.1007/s11684-022-0946-x

Abstract: However, the clinical efficacy is highly variable.variant allele frequencies (VAFs) of ALK fusions can help assess ITH and predict targeted therapy efficacystrong>%, or 20%), the association of ALK subclonality with crizotinib efficacydetermined by hybrid capture-based NGS is probably unreliable for ITH assessment and targeted therapy efficacy

Keywords： ALK fusion     next-generation sequencing     fluorescence in situ hybridization     immunohistochemistry     variant allele frequency     intratumoral heterogeneity     targeted therapy    

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Protective efficacy of vaccination with NcMIC3 and NcMIC8 against

Taotao ZHANG, Xiao ZHANG, Qun LIU, Jianhai XU, Jing LIU

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 2,   Pages 188-196 doi: 10.15302/J-FASE-2019253

Abstract: In this study, we evaluated the protective efficacy of recombinant proteins and DNA vaccines of NcMIC3

Keywords： NcMIC3     NcMIC8     Neospora caninum     vaccination    

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A meta-analysis of randomized trials of maintenance bacillus Calmette-Guerin instillation efficacy against

PAN Jiangang, ZHOU Xing, CHEN Zhiguang, HAN Ruifa

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 259-263 doi: 10.1007/s11684-008-0049-3

Abstract: Meta-analysis was used to determine whether maintenance intravesical bacillus Calmette-Guerin (BCG) could reduce recurrence after transurethral resection of tumor 1 grade 3 (T1G3) superficial bladder cancer. All available published data of randomized clinical trials comparing transurethral resection plus intravesical BCG to either resection alone or resection plus another treatment on the treatment results in patients with superficial bladder cancer of T1G3 were selected for analysis. Both the fixed effects model and random effects model were applied, and the odds ratio () with its 95% confidence interval (CI) was used as the effect size estimate. Sensitivity analysis and publication bias determination were performed by funnel plots and comparing s of different models. Within the follow-up period, 375 of 915 (41.0%) BCG-treated patients and 332 of 733 (45.3%) non-BCG-treated patients developed tumor recurrence. In the combined results, a statistically significant difference in the s for tumor recurrence between the two treatment groups was found (randomized model combined effect 0.58, 95% CI 0.41 to 0.83, = 0.003). The stratified meta-analysis did not show any statistically significant confounding effects on the results when stratified by BCG strains. The randomized model combined effect of Pasteur F and other strains were 0.50 (95% CI 0.26 to 0.95, = 0.04) and 0.63 (95% CI 0.40 to 0.99, = 0.04), respectively. Therefore, we came to the conclusion that adjuvant maintenance instillation BCG combined with transurethral resection of bladder tumor (TURBT) is an effective conservative treatment for preventing recurrence of T1G3 bladder cancer.
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Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 726-745 doi: 10.1007/s11684-020-0746-0

Abstract: Chimeric antigen receptor (CAR) T cells have been indicated effective in treating B cell acute lymphoblastic leukemia and non-Hodgkin lymphoma and have shown encouraging results in preclinical and clinical studies. However, CAR T cells have achieved minimal success against solid malignancies because of the additional obstacles of their insufficient migration into tumors and poor amplification and persistence, in addition to antigen-negative relapse and an immunosuppressive microenvironment. Various preclinical studies are exploring strategies to overcome the above challenges. Mobilization of endogenous immune cells is also necessary for CAR T cells to obtain their optimal therapeutic effect given the importance of the innate immune responses in the elimination of malignant tumors. In this review, we focus on the recent advances in the engineering of CAR T cell therapies to restore the immune response in solid malignancies, especially with CAR T cells acting as cellular carriers to deliver immunomodulators to tumors to mobilize the endogenous immune response. We also explored the sensitizing effects of conventional treatment approaches, such as chemotherapy and radiotherapy, on CAR T cell therapy. Finally, we discuss the combination of CAR T cells with biomaterials or oncolytic viruses to enhance the anti-tumor outcomes of CAR T cell therapies in solid tumors.

Keywords： CAR T cells     immunoregulatory molecules     endogenous immune response     solid malignancies    

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Effects and mechanisms of acupuncture on women related health

Frontiers of Medicine doi: 10.1007/s11684-023-1051-5

Abstract: Globally, public health interventions have resulted in a 30-year increase in women’s life expectancy. However, women’s health has not increased when socioeconomic status is ignored. Women’s health has become a major public health concern, for those women from developing countries are still struggling with infectious and labor-related diseases, and their counterparts in developed countries are suffering from physical and psychological disorders. In recent years, complementary and alternative medicine has attracted wide attentions with regards to maintaining women’s health. Acupuncture, a crucial component of traditional Chinese medicine, has been used to treat many obstetric and gynecological diseases for thousands of years due to its analgesic and anti-inflammatory effects and its effects on stimulating the sympathetic/parasympathetic nervous system. To fully understand the mechanism through which acupuncture exerts its effects in these diseases would significantly extend the list of available interventions and would allow for more reasonable advice to be given to general practitioners. Therefore, by searching PubMed and CNKI regarding the use of acupuncture in treating obstetric and gynecological diseases, we aimed to summarize the proven evidence of using acupuncture in maintaining women’s health by considering both its effectiveness and the underlying mechanisms behind its effects.

Keywords： acupuncture     women health     clinical efficacy     mechanism    

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Experimental study on the efficacy of Fuganling granula on protecting against immunological hepatic injury

Yanli LIU, Rong LIU, Cheng ZHEN, Quanfang GUO, Liping WU, Zhaoxi DING, Yushun BI, Zhiyu LIU

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 91-95 doi: 10.1007/s11684-009-0011-z

Abstract: To study the efficacy of Fuganling granula (FGL, 复肝灵颗粒) in treating mouse immunological hepatic injury

Keywords： Fuganling granula     immunological liver injury     bacille calmette guerin     lipopolysaccharide     mice    

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Title Author Date Type Operation

Clinical trials of the new 3-dimensional reticular intrauterine device for reproductive women

Qiu Yi,Wang Leiguang and Yu Ling

Journal Article

Evaluation of effect of post-abortion contraceptive counseling and education on contraceptive behavior

Yuan Qinqin,Xu Liangzhi,Su Mi and Nie Ying

Journal Article

Meta-analysis of the risk factors of breast cancer concerning reproductive factors and oral contraceptive

Qiong DAI MD, Bei LIU MD, Yukai DU MM,

Journal Article

A review of the safety and efficacy of current COVID-19 vaccines

Journal Article

The status of contraceptive methods uses among women at reproductive age of migrants from different races

Zhang Junxian,Yang Ting,Xu Xiaofan,Long Chunyan,Liu Jiansu,Li Li

Journal Article

Heterogeneous influence of individuals’ behavior on mask efficacy in gathering environments

Journal Article

Retrospective study of the efficacy and complication of thoracoabdominal incision for nephrectomy: a

Minggen YANG, Xiaokun ZHAO

Journal Article

Family planning technical services in China

Shang-Chun WU

Journal Article

Observation on therapeutic efficacy of ursodeoxycholic acid in Chinese patients with primary biliary

Jiangyi Zhu, Yongquan Shi, Xinmin Zhou, Zengshan Li, Xiaofeng Huang, Zheyi Han, Jianhong Wang, Ruian Wang, Jie Ding, Kaichun Wu, Ying Han, Daiming Fan

Journal Article

Potential unreliability of ALK variant allele frequency in the efficacy prediction of targeted therapy

Journal Article

Protective efficacy of vaccination with NcMIC3 and NcMIC8 against

Taotao ZHANG, Xiao ZHANG, Qun LIU, Jianhai XU, Jing LIU

Journal Article

A meta-analysis of randomized trials of maintenance bacillus Calmette-Guerin instillation efficacy against

PAN Jiangang, ZHOU Xing, CHEN Zhiguang, HAN Ruifa

Journal Article

Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

Journal Article

Effects and mechanisms of acupuncture on women related health

Journal Article

Experimental study on the efficacy of Fuganling granula on protecting against immunological hepatic injury

Yanli LIU, Rong LIU, Cheng ZHEN, Quanfang GUO, Liping WU, Zhaoxi DING, Yushun BI, Zhiyu LIU

Journal Article